Opening library…
DrNote Library
Hematology
5 articles
- HematologyHemophilia A and BHemophilia A and B are inherited bleeding disorders caused by deficiency or dysfunction of coagulation factor VIII (FVIII) or factor IX (FIX), respectively. Both are usually X-linked. The bleeding phenotype is driven…13 min read
- HematologyImmune Thrombotic Thrombocytopenic PurpuraImmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy caused by severe acquired deficiency of ADAMTS13, usually from inhibitory or clearance-enhancing autoantibodies. The r…16 min read
- HematologyIron Deficiency AnemiaIron deficiency anemia (IDA) results when iron available for erythropoiesis is insufficient to sustain normal hemoglobin production. The clinical task has two parallel parts: replace iron and identify why iron was los…20 min read
- HematologySickle Cell DiseaseSickle cell disease (SCD) is a group of inherited hemoglobin disorders in which hemoglobin S (HbS) polymerizes when deoxygenated, causing red-cell deformation, hemolysis, inflammation, endothelial adhesion, vaso-occlu…14 min read
- HematologyVitamin B12 Deficiency in AdultsVitamin B12 deficiency is a potentially reversible cause of hematologic, neurologic, psychiatric, and mucosal disease. Neurologic injury can occur without anemia or macrocytosis; a normal mean corpuscular volume there…10 min read